Video venöse Ulzera Fragliche Wirksamkeit autologer thrombozytärer Wachstumsfaktoren (PDWHF) in der Behandlung venöser Beinulzera | Springer for Research & Development
Accedi Campi nascosti Brevetti The invention relates to biomedical foam articles for wounds, which are obtained by spraying Thrombophlebitis Anschlag polymer dispersion onto a wound. The polymer dispersion is transformed into a three-dimensional molded body which adjusts to the three-dimensional shape of the wound when the polymer dispersion is sprayed http://newohioreview.com/blog/struempfe-von-krampfadern-kaufen-in-minsk.php The invention relates to biomedical foam articles for wounds, which are obtained by spraying a polymer dispersion onto a wound.
The polymer dispersion is transformed into a three-dimensional molded body which adjusts to the three-dimensional shape of the wound when the polymer dispersion is sprayed onto a surface of the wound and ensures that the wound is entirely dressed in an accurately fitting manner also in the depth dimension in Video venöse Ulzera to covering the surface of the wound.
The inventive biomedical foam articles are suitable especially for treating chronic wounds. Biomedical foam Video venöse Ulzera for the wound sector, obtainable by spraying a composition comprising at least one ionic polymeric dispersion or emulsion, at least one coagulant and also a foam auxiliary directly onto the skin, in particular onto a wound.
Biomedical foam article according to Claim 1, Video venöse Ulzera in that the ionic polymeric dispersion or emulsion is selected from ionic rubber latex dispersions, ionic polyurethane dispersions, dispersions of ionic meth acrylate copolymers and dispersions of naturally occurring ionic biopolymers based on carbohydrate such as cellulose derivatives, for example cellulose acetate phthalate CAPcellulose acetate succinate CAScellulose acetate trimelitate CAThydroxypropylmethylcellulose phthalate HPMCPcarboxymethylcellulose CMCchitosan, as well as Video venöse Ulzera, hyaluronan, dextrin, cellulose or starch and also further natural biopolymers such as, for example, lignin or casein.
Biomedical foam article according to Claim 1 or 2, characterized in that the ionic polymeric dispersion or emulsion is selected from aqueous polyurethane dispersions, aliphatic polyurethane dispersions and polyurethane hybrid emulsions. Biomedical foam article according to any one of Claims 1 to 3, characterized in Video venöse Ulzera the знал, Stimmungen Sytina mit Krampfadern für Frauen соединялась polymeric dispersion or emulsion is an aqueous anionic hydrophilic polyurethane dispersion.
Biomedical foam article according to any one of Claims 1 to 3, characterized in that the ionic polymeric dispersion or emulsion is an aqueous anionic hydrophilic polyurethane dispersion obtainable by.
A isocyanate-functional prepolymers being prepared from. Biomedical foam article according to Claim 5 or 6, characterized in that the cationic coagulant II is an acrylamide copolymer comprising structural units of the general formula 1 and 2. The present invention relates Video venöse Ulzera biomedical foam article for the wound area, which are obtained by spraying a polymer onto a wound. The polymer obtained during spraying to a wound surface one hand, the spatial shape of the wound adaptive three-dimensional shaped body which ensures not only Video venöse Ulzera the wound surface, a complete and exact fit lining of the wound in the depth dimension and beyond has strongly absorbing properties.
The biomedical foam articles of the invention are particularly suitable for the treatment of chronic wounds. As chronic wounds all wounds are referred to, are not epithelialized within a physiological healing time of weeks. Die mit Abstand häufigsten Video venöse Ulzera chronischer Wunden sind Dekubitalulzera verursacht go here chronische Druckbelastungchronisch-venöse Ulzera der Beine verursacht durch chronisch venöse Video venöse Ulzera und diabetische Ulzera verursacht durch Angiopathie und Neuropathie.
By far the most common forms of chronic wounds are pressure sores caused by chronic pressurechronic Video venöse Ulzera ulcers of the legs caused by chronic venous insufficiency and diabetic ulcers caused by angiopathy and neuropathy.
The standard treatment of chronic wounds follows the principle of "moist wound healing" with different wound dressing materials.
Die typischen Materialien der feuchten Wundbehandlung werden als Vliese auf die Wunde aufgelegt, Video venöse Ulzera eine optimale Wundabdeckung zu erhalten und durch Aufrechterhaltung des feuchten Wundmilieus die Wundheilung zu beschleunigen. The materials typical of moist wound treatment will be established as webs on the wound in order to obtain an optimal wound coverage and speed by maintaining the moist wound environment wound healing.
However, Video venöse Ulzera extension of conventional methods of treatment of chronic wounds has the disadvantage that conventional wound dressings merely cover the wound surface, but not three-dimensional line the wound especially in depthresulting in deficiencies in Exudathandling, increased risk of infection but also increased maceration at the wound edges may cause.
A lack of wound lining may lead to Exudatansammlungen the wound bed, which ultimately results in addition to a disability wound healing also to a softening of the healthy tissue at the wound edge and maceration eg cavitären wounds. Das Video venöse Ulzera von überschüssigem Exudat begünstigt weiterhin das Entstehen von Infektionen. The presence of excess exudate favors further the occurrence of infections. The disadvantage of such a though, is that he does not always lead to a precise fit lining of the wound in the depth dimension.
Weiterhin Video venöse Ulzera ein solcher Wundverband umständlich zu handhaben und unter Umständen nur schwierig steril zu halten. Furthermore, such a wound dressing is awkward to handle and difficult to keep sterile circumstances.
The polysiloxane foam thus formed is Video venöse Ulzera highly absorbent and go here can be used for wounds which Video venöse Ulzera large amounts of wound fluid, not be used. Weitere wichtige Eigenschaften sind eine schnelle Aushärtung sowie eine ausreichende Flüssigkeitsausnahme Absorption des die Wundauflage bildenden Materials.
Other Video venöse Ulzera characteristics are fast curing and adequate fluid exception absorption of the dressing-forming material. Prerequisite for an effective use is fast curing ie, solidification of the liquid polymer to a solid foam articles, determined by sensory examination of the viscosity of the biomedical foam article Video venöse Ulzera a time of no longer http://newohioreview.com/blog/video-bungen-fuer-die-beine-von-krampfadern.php five minutes, preferably not more than 2 minutes, more preferably not more than one minute, most Video venöse Ulzera less than 30 seconds.
This requires that foam has an at least partially open-cell structure. It has now been found, surprisingly, Video venöse Ulzera this object is achieved by the invention described below biomedical foam article. A first object of the present invention is a biomedical foam article obtainable by the spraying of a composition comprising at least one ionic polymeric dispersion or emulsion, at least more info coagulant, and one foaming agent and, optionally, at least one active compound selected from the group of broad-spectrum antibiotics, antiseptics, antivirals, the antifungal agents, the antipathogenic peptides, the local anesthetics, the nichtsteroidaten anti-inflammatory drugs, opiates and haemostatic, wound healing, granulation agents acting on a Sübstrat.
A preferred substrate is the human or animal skin, comprising one or more wound sites. The advantages of spray application are in particular the handling of the product. Durch die Applikation einer Fertiglösung aus einer sterilen Spraydose entfällt das Entpacken, Zurechtschneiden und Auflegen der herkömmlichen Materialien dh die Applikation kann sogar durch den Patienten selbst durchgeführt werden, beschleunigt den Vorgang des Verbandwechsels und Video venöse Ulzera hygienischer, da der direkte manuelle Kontakt mit der Wunde beim Verbandswechsel entfällt.
By applying a finishing solution from a sterile spray unpacking, cropping and placement of the conventional materials eliminates ie, the application can even be performed by the patient himself, accelerates the process of dressing changes and is more hygienic, since direct manual contact with the wound dressing changes not applicable. Preferred ionic polymer dispersions as a continuous phase have a water-containing medium is.
Celluloseacetatphthalat CAPCellutoseacetatsuccinat CASCelluloseacetattrimelitat CATHydroxypropylmethylcellulosephthalat HPMCPCarboxymethylcellulose CMCChitosan, auch Chitin, Hyaluronan, Cellulose, Dextrin oder Stärke sowie weiterer natürlicher Biopolymere wie zB Lignin oder Casein. Suitable ionic polymer dispersions of http://newohioreview.com/blog/krampfadern-und-schwellungen.php type mentioned above are for example ionic rubber latex dispersions, ionic polyurethane dispersions, dispersions of ionic meth acrylate copolymers and Video venöse Ulzera of naturally occurring ionic biopolymers based on carbohydrate such as cellulose derivatives, eg.
As cellulose acetate phthalate CAPCellutoseacetatsuccinat CASCelluloseacetattrimelitat CAThydroxypropylmethylcellulose phthalate HPMCPcarboxymethyl cellulose CMCchitosan, chitin, hyaluronan, cellulose, dextrin or starch and other natural biopolymers such Video venöse Ulzera lignin or casein.
To C 4 -alkyl esters of acrylic or methacrylic acid and containing 5 to 60 wt. As a rule, the proportions mentioned add up to wt. Es können jedoch zusätzlich, ohne dass dies zu einer Beeinträchtigung oder Veränderung der wesentlichen Eigenschaften führt, geringe Mengen more info Bereich von 0 bis 10, z.
Hydroxyethylmethacrylat oder Hydroxyethylacrylat enthalten sein. Video venöse Ulzera, however, without this leading to an impairment or alteration of the essential properties, for small amounts in the range of 0 to 10, z. As hydroxyethyl methacrylate or hydroxyethyl be included. Preferred ionic polymer dispersions are aqueous, ionic polyurethane dispersions, aliphatic polyurethane dispersions and polyurethane hybrid emulsions. Besonders bevorzugte Polymerdispersionen sind wässrige, Video venöse Ulzera, hydrophile Polyurethan -Dispersionen.
Particularly preferred polymer dispersions are aqueous anionic hydrophilic polyurethane dispersions. Preferred aqueous anionic polyurethane dispersions I has a low degree of hydrophilic anionic groups, preferably from 0. In order to achieve good sedimentation stability, the Video venöse Ulzera average particle size of the specific polyurethane dispersions is preferably less than nm, more preferably less than nm, determined by laser correlation spectroscopy.
The ratio of NCO groups of the compounds of component A1 to NCO-reactive groups such as amino, hydroxyl or thiol groups of the compounds of components A2 to A4 is in the preparation of the NCO-functional prepolymer, 1. Particular preference is given in A1 of 1,6-hexamethylene diisocyanate, isophorone diisocyanate, the isomeric bis 4,4'-isocyanatocyclohexyl methanes, and also mixtures thereof.
Diese weisen bevorzugt eine OH-Funktionalität von 1,5 bis 6, besonders bevorzugt von 1,8 bis 3, ganz besonders bevorzugt von 1,9 bis 2,1 auf. These preferably have an OH functionality of 1. Such polymeric polyols are in polyurethane coatings technology known polyester, polyacrylate polyols, polyurethane, polycarbonate polyols, polyether polyols, Polyesterpolyacrylatpolyole, Polyurethanpolyacrylatpolyole, Polyurethanpolyesterpolyole, Polyurethanpolyetherpolyole, Polyurethanpolycarbonatpolyole and Polyesterpolycarbonatpolyole.
Diese können in A2 einzeln oder in beliebigen Mischungen untereinander eingesetzt werden. These can be used in any mixtures with Video venöse Ulzera another in A2 or. Such polyester polyols are the polycondensates of di- and optionally tri- and tetra-ols and di- and optionally tri- and tetracarboxylic acids or hydroxy carboxylic acids or lactones. Anstelle der freien Polycarbonsäuren können auch check this out entsprechenden Polycarbonsäureanhydride oder entsprechende Polycarbonsäureester von niederen Alkoholen zur Herstellung der Polyester verwendet werden.
Instead Video venöse Ulzera the free polycarboxylic acids, the corresponding polycarboxylic acid anhydrides or corresponding polycarboxylic esters of lower alcohols may be Bad Thrombophlebitis for preparing the polyesters. Examples of suitable diols are ethylene glycol, butylene glycol, diethylene glycol, triethylene glycol, polyalkylene glycols such as polyethylene glycol, and also 1,2-propanediol, 1,3-propanediol, butanediol 1,3butanediol 1,4hexanediol 1,6 and isomers, neopentyl glycol or hydroxypivalate, with hexane 1.
Daneben können auch Polyole wie Trimethylolpropan, Glycerin, Erythrit, Pentaerythrit, Triemthylolbenzol oder Trishydroxyethylisocyanurat eingesetzt werden. In Video venöse Ulzera, polyols such as trimethylolpropane, glycerol, erythritol, pentaerythritol, trimethylolbenzene or trishydroxyethyl isocyanurate. Als Säurequelle können auch die entsprechenden Anhydride verwendet werden. As a source of acid the corresponding anhydrides can be used. Besonders bevorzugt sind Adipinsäure, Isophthalsäure und gegebenenfalls Trimellithsäure.
Preferred acids are aliphatic or aromatic acids of the type mentioned above. Especially preferred are adipic acid, isophthalic acid and optionally trimellitic acid. Hydroxycarboxylic acids, which may be used as reactants in the preparation of a polyester polyol having terminal hydroxyl groups include for example hydroxycaproic acid, hydroxybutyric acid, hydroxy decanoic acid, hydroxystearic acid and the like.
Geeignete Lactone sind Caprolacton, Butyrolacton und Homologe. Suitable lactones are caprolactone, butyrolactone and homologues. Diese sind durch Reaktion von Kohlensäurederivaten, wie Diphenylcarbonat, Dimethylcarbonat oder Phosgen, mit Polyolen, bevorzugt Diolen, erhältlich.
These are obtainable Video venöse Ulzera reaction of carbonic acid derivatives, such as diphenyl carbonate, dimethyl carbonate or phosgene, with polyols, preferably diols.
Examples of such diols are ethylene glycol, 1,2- and 1,3-propanediol, 1,3- and 1,4-butanediol, 1,6-hexanediol, 1,8-octanediol, neopentyl glycol, 1,4-bis-hydroxymethyl cyclohexane, 2- methyl-1,3-propanediol, 2,2,4-trimethylpentanediol-1,3, dipropylene Video venöse Ulzera, polypropylene glycols, dibutylene glycol, polybutylene glycols, bisphenol A and lactone-modified diols of the aforementioned kind. The polycarbonate preferably contains 40 Ursachen der Speiseröhre Ursachen wt.
Solche Hexandiolderivate basieren auf Hexandiol und weisen neben endständigen OH-Gruppen Ester- oder Ethergruppen auf. Such hexanediol derivatives are based on hexanediol and besides terminal OH groups ester or ether groups. Solche Derivate sind durch Reaktion von Hexandiol mit überschüssigem Caprolacton oder durch Video venöse Ulzera von Hexandiol mit sich selbst zum Di- oder Trihexylenglykol erhältlich. Such derivatives are obtainable by reaction of hexanediol with excess caprolactone or by etherification of hexanediol with Video venöse Ulzera to form di- or tri-hexylene glycol.
Instead of or in addition to pure polycarbonate, polyether polycarbonate in A2 can be used. Hydroxyl-containing polycarbonates preferably have a linear. Also can be Video venöse Ulzera in A2 polyether polyols. Suitable examples are in polyurethane chemistry polytetramethylene as obtainable by polymerizing tetrahydrofuran by means Video venöse Ulzera cationic ring opening. Polyetherpolyole, basierend auf der zumindest anteiligen Addition von Ethylenoxid an di- oder polyfunktionelle Startermoleküle, können auch als Komponente A4 eingesetzt werden nichtionische Hydrophilierungsmittel.
Polyether polyols based on the at least proportional addition of ethylene oxide to di- or polyfunctional starter molecules, can also be used as component A4 nonionic hydrophilicizing agents. Useful starter molecules include all be used with the prior art compounds, such as water, butyldiglycol, glycerol, diethylene glycol, trimethylolpropane, propylene glycol, sorbitol, ethylene diamine, read more, 1,4-butanediol.
Bevorzugte Startermoleküle sind Wasser, Ethylenglykol, Propylenglykol, 1,4-Butandiol, Diethylenglykol und Butyldiglykol. Preferred starter molecules are Video venöse Ulzera, ethylene glycol, propylene glycol, 1,4-butanediol, Video venöse Ulzera glycol and butyldiglycol. Particularly preferred embodiments of the polyurethane dispersions Http://newohioreview.com/blog/varizen-honig-salz.php comprise, as component Video venöse Ulzera a mixture Video venöse Ulzera polycarbonate polyols and polytetramethylene glycol polyols, wherein in said Nicht-chirurgische von Krampfadern Laser the proportion of polycarbonate polyols in the mixture 20 to 80 wt.
Bevorzugt ist ein Video venöse Ulzera von 30 bis 75 Gew. Preferred is a read article of 30 to 75 wt.
Besonders bevorzugt ist ein Anteil von 35 bis 70 Gew. Particularly preferred is a proportion of 35 to 70 wt. A3 may polyols of the specified Video venöse Ulzera weight range of up to 20 carbon atoms, such as ethylene glycol, diethylene glycol, triethylene glycol, 1,2-propanediol, 1,3-propanediol, 1,4-butanediol, 1,3-butylene glycol, cyclohexanediol, 1,4 -Cyclohexandimethanol, 1,6-hexanediol, neopentyl glycol, hydroquinone dihydroxyethyl ether, bisphenol A 2,2-bis 4-hydroxyphenyl propanehydrogenated bisphenol A, 2,2-bis 4-hydroxycyclohexyl propanetrimethylol propane, glycerolpentaerythritol, and any mixtures thereof with one another.
Further, monofunctional isocyanate, hydroxyl group-containing compounds may be used in A3. Beispiele Video venöse Ulzera monofunktionellen Verbindungen sind Ethanol, n-Butanol, Ethylenglykolmonobutylether, Diethylenglykolmonomethylether, Ethylenglykolmonobutylether, Diethylenglykolmonobutylether, Propylenglykolmonomethylether, Dipropylenglykol-monomethylether, Tripropylenglykolmonomethylether, Dipropylenglykolmonopropylether, Propylenglykolmonobutylether, Dipropylenglykolmonobutylether, Tripropylenglykolmonobutylether, 2-Ethylhexanol, 1-Octanol, 1-Dodecanol, 1-Hexadecanol.
Examples of such monofunctional compounds are ethanol, n-butanol, ethylene glycol monobutyl Video venöse Ulzera, diethylene glycol monomethyl ether, ethylene glycol monobutyl ether, diethylene glycol monobutyl ether, propylene glycol monomethyl ether, dipropylene glycol monomethyl ether, tripropylene glycol monomethyl ether, dipropylene glycol monopropyl ether, propylene glycol Video venöse Ulzera ether, dipropylene glycol monobutyl Video venöse Ulzera, Tripropylenglykolmonobutylether, 2-ethylhexanol, 1-octanol, 1-dodecanol, 1-hexadecanol[] [] Bevorzugte Verbindungen der Komponente A3 sind 1,6-Hexandiol.
Preferred compounds of component A3 are 1,6-hexanediol. Geeignete anionisch oder potentiell anionisch hydrophilierende Verbindungen sind Mono- und Dihydroxycarbonsäuren, Mono- und Dihydroxysulfonsäuren, sowie Mono- und Dihydroxyphosphonsäuren und ihre Salze. Suitable anionic or potentially anionic link compounds include mono- and dihydroxy, mono- and dihydroxy, and mono- and dihydroxy acid and its salts.
Beispiele solcher anionischen bzw. Particularly preferred anionic or potentially anionic hydrophilicizing agents are those that contain carboxylate or carboxyl groups as ionic or potentially ionic groups, such as dimethylol dimethylolbutyric and hydroxypivalic acid and salts thereof. Suitable nonionic hydrophilic compounds of component A4 include polyoxyalkylene ethers containing at least one hydroxyl or amino group preferably contain at least one hydroxyl group.
Auflage, Band 19, Verlag Chemie, Weinheim S. Examples Video venöse Ulzera the monohydroxy, on average 5 to 70, preferably 7 to 55 ethylene oxide units per molecule comprising polyalkylene oxide polyether, such as those accessible by alkoxylation of suitable Starterinoleküle in a conventional manner eg, in Video venöse Ulzera Encyclopedia of Industrial Chemistry, 4th Edition, Volume 19Verlag Chemie, Weinheim, pp Preferred nonionic hydrophilic compounds of component A4 are those of the type mentioned above, which are block co polymers prepared by blockwise addition of alkylene oxides onto suitable starters.
Suitable starter molecules for such nonionic hydrophilicizing agents include saturated monohydric alcohols such as methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, sec-butanol, the isomers pentanols, hexanols, octanols and nonanols, n-decanol, n-dodecanol, n tetradecanol, n-hexadecanol, n-octadecanol, cyclohexanol, the isomeric methylcyclohexanols or hydroxymethyl, 3-ethylhydroxymethyl oxetane or tetrahydrofurfuryl alcohol, diethylene glycol, such as diethylene glycol monobutyl ether, unsaturated alcohols such as allyl alcohol, 1,1-dimethylallyl alcohol or oleyl alcohol, aromatic Video venöse Ulzera such as phenol, the isomeric cresols or methoxyphenols, araliphatic alcohols such as benzyl alcohol, anisyl alcohol or cinnamyl alcohol, secondary monoamines such as dimethylamine, diethylamine, dipropylamine, diisopropylamine, dibutyl amine, Video venöse Ulzera 2-ethylhexyl amine, N-methyl and N-ethyl-cyclohexylamine or dicyclohexylamine and heterocyclic secondary amines such as morpholine, pyrrolidine, piperidine or 1H-pyrazole.
Bevorzugte Startermoleküle sind gesättigte Monoalkohole der vorstehend genannten Art. Besonders bevorzugt werden Diethylenglykolmonobutylether oder n-Butanol als Startermoleküle verwendet.
Preferred starter molecules are saturated mono alcohols of the type mentioned above. Diethylene glycol Video venöse Ulzera ether or n-butanol are particularly preferably used as starter molecules.
Suitable for the alkoxylation alkylene oxides are ethylene oxide and propylene oxide, which can be used in any order or in admixture in the alkoxylation reaction.
Ebenfalls möglich, aber weniger bevorzugt, ist die Verwendung von Hydrazin oder sowie Hydraziden wie Adipinsäuredihydrazid. Is also possible but less preferable to the use of hydrazine or hydrazides such Video venöse Ulzera adipic acid. In Video venöse Ulzera, may have, are used as component B1compounds which, besides a primary amino group and secondary amino groups or, besides an Video venöse Ulzera group primary or secondaryalso have OH groups. Preferred compounds of component B1 are 1,2-ethylenediamine, 1,4-diaminobutane and isophoronediamine.
Suitable anionic or potentially anionic hydrophilic compounds are mono- and diamino, mono- and diamino and mono- and diaminophosphonic and their salts. Mixtures of anionic or potentially anionic and nonionic hydrophilicizing hydrophilising also can be used to hydrophilicization.
Nach vollständig oder teilweise durchgeführter Polyaddition aus A1 bis A4 Krampfadern den Oberschenkel in ein Dispergier- Emulgier- oder Lösungsschritt. After completely or Video venöse Ulzera conducted polyaddition Hormone und Krampfadern A1 to A4 a dispersing, click here or dissolving step.
Video venöse Ulzera Anschluss erfolgt gegebenenfalls eine weitere Polyaddition oder Modifikation in disperser Phase.
This is followed where appropriate by a further polyaddition or modification in disperse phase. In this case, all known from the prior art methods such as the prepolymer Video venöse Ulzera process, the acetone process or http://newohioreview.com/blog/volks-behandlung-von-krampfadern-der-speiseroehre.php melt can be used.
Bevorzugt wird das Aceton-Verfahren verwendet. Preferably, Video venöse Ulzera acetone process is used. Zur Beschleunigung der Isocyanatadditionsreaktion können die in der Verletzung Hirndurchblutung Polyurethan-Chemie bekannten Katalysatoren eingesetzt werden. To accelerate the isocyanate known in polyurethane chemistry catalysts can be used. Suitable solvents are the customary aliphatic, keto-functional solvents such as acetone, 2-butanone, which can be added not only at the beginning of the preparation but optionally also later in portions.
Dorn von trophischen Geschwüren sind Aceton und 2-Butanon. Preferably acetone and 2-butanone are. Other solvents such as xylene, toluene, cyclohexane, butyl, methoxy propyl acetate, N-methylpyrrolidone, N-ethyl pyrrolidone, solvents having ether or ester units can additionally be used or wholly or partly distilled off or completely in the case of N-methylpyrrolidone, N-ethyl pyrrolidone in the dispersion remain.
But no Video venöse Ulzera solvents are preferred in addition to the conventional aliphatic, keto-functional solvents used. Subsequently, optionally at the beginning of the reaction is not added the ingredients of A1 are metered to A4. In the preparation of the polyurethane prepolymers from A1 to A4the molar ratio of isocyanate groups to isocyanate-reactive groups is from 1.
The reaction of components A1 to A4 to form the prepolymer takes place partially or completely, but preferably completely. Es werden so Polyurethan-Prepolymere, die freie Isocyanatgruppen enthalten, in Video venöse Ulzera oder in Lösung erhalten.
In this way polyurethane prepolymers containing free isocyanate groups are obtained in bulk or in solution. In the neutralization step for the partial or complete conversion of potentially anionic groups to anionic groups, bases such as tertiary amines, such article source trialkyl amines with 1 to 12, preferably from 1 to 6 carbon atoms, more preferably 2 to 3 carbon atoms in each alkyl radical or alkali metal bases such as the corresponding hydroxides.
Examples of these are trimethylamine, triethylamine, methyldiethylamine, tripropylamine, N-methylmorpholine, methyldiisopropylamine, ethyldiisopropylamine and diisopropylethylamine. Die Alkylreste können beispielsweise auch Hydroxylgruppen tragen, wie bei den Dialkylmonoalkanol- Alkyldialkanol- und Trialkanolaminen. The alkyl radicals may also bear for example hydroxyl groups, as in the dialkylmonoalkanol- alkyldialkanol- and trialkanolamines. Als Neutralisationsmittel sind gegebenenfalls auch anorganische Basen, wie wässrige Ammoniaklösung oder Natrium- bzw.
As a neutralizing agent, inorganic bases such as aqueous http://newohioreview.com/blog/kompressionsstruempfe-krampfadern.php solution or sodium hydroxide or potassium hydroxide are optionally used. Preferred are ammonia, triethylamine, triethanolamine, Video venöse Ulzera or diisopropylethylamine, and sodium hydroxide and Video venöse Ulzera hydroxide, more preferably sodium hydroxide and potassium hydroxide.
Die Neutralisation kann auch gleichzeitig mit der Dispergierung erfolgen, in dem das Dispergierwasser bereits das Neutralisationsmittel enthält. The neutralization can also take place simultaneously with dispersing, with the dispersing water already contains the neutralizing agent.
Im Anschluss wird in einem weiteren Verfahrensschritt, falls noch nicht oder nur teilweise geschehen das erhaltene Prepolymer mit Hilfe von aliphatischen Ketonen Video venöse Ulzera Aceton oder 2-Butanon gelöst. Following is if it has not or only partly Video venöse Ulzera obtained is dissolved using aliphatic ketones such as acetone or 2-butanone in a further step. When partial or complete chain extension anionic or potentially anionic hydrophilicizing according to the definition B2 with NH 2 - or NH groups, chain extension of the prepolymers is preferably prior to dispersing.
The amine components B1 and B2 can optionally be used in mixtures, in principle any sequence of addition is possible individually in water- or solvent-diluted form in the process according to the invention or. If water or organic solvents are used as diluents, the diluent content in the used in B component for chain extension is preferably 70 to 95 wt.
Dispersion is preferably carried out following chain extension. Dazu wird das gelöste und kettenverlängerte Polyurethanpolymer gegebenenfalls unter starker Scherung, wie zB starkem Rühren, entweder in das Dispergierwasser eingetragen oder es wird umgekehrt das Dispergierwasser zu den kettenverlängerten Polyurethanpolymerlösungen gerührt.
For this purpose, Video venöse Ulzera dissolved and chain-extended polyurethane polymer optionally with strong shearing, such as vigorous stirring, either Video venöse Ulzera into the dispersing or conversely stirred the dispersing of the chain-extended polyurethane polymer solutions. Bevorzugt wird das Wasser in das gelöste kettenverlängerte Polyurethan polymer gegeben. Preferably the water is added to the dissolved chain-extended polyurethane polymer.
The solvent in the dispersions after the dispersion still present is then usually removed by distillation. Eine Entfernung bereits während der Dispergierung ist ebenfalls möglich. Removal during the dispersing is also possible. The residual content of organic solvents in the polyurethane dispersions I is typically less than 1.
The pH of the inventively essential polyurethane dispersions I is typically less than 9. The solids content of the polyurethane dispersions I is 40 to 70, preferably 50 to 65, particularly preferably 55 to 65 wt. As coagulants II are typically at least 2 cationic groups containing organic compounds, preferably all known cationic flocculating Video venöse Ulzera precipitating agent of the prior art, such as cationic homo- or copolymers Video venöse Ulzera a salt Video venöse Ulzera poly [2- N, N, N-trimethylamino -ethylacrylats], polyethyleneimine, poly [N- dimethylaminomethyl acrylamide], substituted acrylamides, substituted methacrylamide, N-vinyl Video venöse Ulzera, N-vinylacetamide, N-vinylimidazole, 2-vinylpyridine or 4-vinylpyridine used.
The residual amounts of monomers, in particular acrylate and acrylamide monomers, in the coagulants are preferably less than 1 wt.
The coagulants can be used in solid form or as aqueous solutions http://newohioreview.com/blog/was-die-beste-creme-fuer-krampfadern.php dispersions. Bevorzugt ist die Verwendung von wässrigen Dispersionen bzw.
Preferred is the use of aqueous dispersions or solutions. Foam auxiliaries such as foam and - stabilizers are preferably used. Geeignet sind beispielsweise handelsübliche Verbindungen wie Fettsäureamide, Sulfosuccinamide, Kohlenwasserstoffsulfonate, -sulfate oder Fettsäuresalze, wobei der lipophile Rest bevorzugt 12 bis 24 Kohlenstoffatome enthält.
Suitable examples are commercially available compounds such as fatty acid amides, sulfosuccinamides, hydrocarbyl, sulfates or fatty acid salts, wherein the lipophilic radical preferably contains from 12 to 24 carbon atoms. Preferred foam auxiliaries are alkane sulfonates or sulfates containing 12 to 22 carbon atoms in the hydrocarbon radical, alkylbenzosulphonates or sulfates having 14 to 24 carbon atoms in the hydrocarbon click at this page Video venöse Ulzera fatty acids or fatty acid salts having 12 to click carbon atoms.
Such fatty acid amides are preferably those based on mono- or di- C -alkanol amines. Die Fettsäuresalze können beispielsweise Alkalimetallsalze, Aminsatze oder unsubstituierte Ammoniumsalze sein.
The fatty acid salts may be for example alkali metal salts, amine sentence or unsubstituted ammonium salts. Such fatty acid derivatives are typically based on fatty acids such as lauric acid, myristic acid, palmitic acid, oleic acid, stearic acid, ricinoleic acid, behenic acid or arachic acid, coconut fatty acid, tallow fatty acid, soya fatty acid and their hydrogenation products. Particularly preferred Video venöse Ulzera mixtures of Schaumhüfsmittel sulfosuccinamides and ammonium, which preferably 20 to 60 wt.
In addition to the polyurethane dispersions I and the coagulants II and other auxiliaries and additives III can be used. Suitable thickeners commercial thickeners can be used, such as dextrin, starch or cellulose derivatives such as cellulose or hydroxyethyl cellulose, organic wholly synthetic thickeners based on polyacrylic acids, polyvinylpyrrolidones, acrylic compounds poly meth or polyurethanes associative thickeners and also inorganic thickeners, such as bentonite or Leggings Krampfadern. In principle, although not preferred, the invention substantially compositions also contain crosslinkers such as unblocked polyisocyanates, amide, and amine-formaldehyde resins, phenolic resins, aldehyde and Video venöse Ulzera resins, such as phenol-formaldehyde resins, resols, furan resins, urea resins, Carbamidsäureesterharze, triazine resins, melamine resins, benzoguanamine resinscyanamide or aniline resins.
The invention substantially compositions contain on a dry matter typically 80 to Preferably, the invention substantially compositions contain, based on dry substance 8. The invention more preferably substantially compositions contain on a Video venöse Ulzera matter 89 to 97 parts by weight of the dispersion Ifrom 0.
In addition to components III and optionally IIIother aqueous binders can be used Dressings mit Geschwüren Video the present essentially Krampfadern Stadium der Entwicklung. Solche wässrigen Bindemittel können zB aus Polyester- Polyacrylat- Polyepoxid- oder anderen Polyurethanpolymeren aufgebaut sein.
Such aqueous binders for example may be когда Injektionen in die Vene von Krampfadern Bewertungen вел of polyester, polyacrylate, polyepoxide or other polyurethane polymers. Auch die Kombination mit strahlenhärtbaren Bindemitteln, wie sie zB in der Also, the combination with radiation-curable binders, as for example in the EP-A-0 EP-A beschrieben sind, ist möglich.
Ferner können auch andere anionische oder nicht-ionische Dispersionen, wie Polyvinylacetat- Polyethylen- Polystyrol- Polybutadien- Polyvinylchlorid- Polyacrylat- und Copolymerisat-Dispersionen eingesetzt werden.
Also, other anionic or non-ionic dispersions, such as polyvinyl acetate, polyethylene, polystyrene, Video venöse Ulzera, polyvinyl chloride, polyacrylate and copolymer dispersions may be used. Foaming in the process according to the invention is accomplished by mechanical stirring of the composition at high speeds or by decompressing a blowing gas. Mechanical foaming can be done with any desired mechanical stirring, mixing and dispersing.
In der Regel wird Video venöse Ulzera Luft eingetragen, Video venöse Ulzera auch Stickstoff und andere Gase können hierfür benutzt werden. As a rule, air is introduced, but nitrogen and other gases can be used for this purpose. The foam thus obtained is placed in the foaming or thereafter applied directly to a substrate or in a mold and dried.
The contract, for example, by pouring Varizen gefährlich knife done, but also Video venöse Ulzera known per se techniques are possible. Ein mehrschichtiger Auftrag mit zwischengeschalteten Video venöse Ulzera ist grundsätzlich auch möglich. A multi-layer application with intermediate drying steps is also possible in principle. Möglich ist auch eine zwei- oder mehrstufige Trocknung.
It is also a two- or multi-stage drying. The polymer dispersion or emulsion used in the invention may Video venöse Ulzera contain see more active substances in amounts effective or get added. The biomedical foam articles of the invention can, for example, local anesthetics, enzymes, antibacterial or antifungal drugs or hormonal compounds.
The biomedical foam articles of the invention are particularly suitable for the treatment of skin wounds, particularly chronic wounds such as diabetic, venous, pressure ulcers, but also of burn wounds and acute wounds, particularly minimal acute wounds. They provide a complete, precise-fit lining of the wound in the depth dimension, have a fast cure and good fluid intake and are easy to handle. Unless indicated otherwise, all percentages are by weight.
NCO contents, unless expressly mentioned otherwise determined volumetrically in accordance with DIN EN ISO The average particle sizes is the number average of the Video venöse Ulzera dispersions 1 by means of laser correlation spectroscopy instrument: Malvern ZetasizerMalvern Inst. Was then added over 5 min, a mixture of Die Nachrührzeit betrug 10 min.
Stirring was Beine wirksame Medikamente for 10 min. Dann wurde durch Zugabe von g Wasser dispergiert. It was then dispersed by adding g of Video venöse Ulzera. Es folgte die Entfernung des Lösemittels durch Destillation im Vakuum.
This was followed by removal of the click the following article by distillation in vacuo.
Then was dispersed by addition of g of water. Was then added over 5 min a mixture of Video venöse Ulzera amounts shown in Table Video venöse Ulzera, the polyurethane dispersions Video venöse Ulzera in Examples described were marked with the foam aids such there as well mixed and opened using a commercially available hand stirrer stirrer made of bent wire to 1 liter foam volume. Danach wurden die Schäume mittels eines Filmziehgerätes RakelSpalthöhe in der Check this out 1 angegeben, auf siliconbeschichtetes Papier aufgezogen.
Thereafter, the foams using a film-drawing device Squeegeegap height specified in Table 1, mounted on silicone coated paper. In der Tabelle 1 sind ebenso die Trocknungsbedingungen der wie angegeben hergestellten Schäume aufgeführt.
In Table 1, the drying conditions of the foams produced are also shown as indicated. There were consistently obtained in pure white foams having good mechanical properties and a fine pore structure. Tabelle 1 Table 1 Menge [g] Quantity [g] Schaum Nr. As Table 2 it видели, Thrombophlebitis Wiederholung упоминал be seen all foams showed a very rapid uptake of water, a high absorption of physiological saline "free swell way"a very good water vapor Video venöse Ulzera rate "MVTR" and, moreover, good Video venöse Ulzera strength, especially after moist storage.
Tabelle 2 Table 2 Schaum Nr. Nach dem Sprühen ca. After spraying about 1 cm wet film thickness and drying at ambient conditions Video venöse Ulzera a clean white, fine foam. Effective date: Ref country code: NL Ref legal event code: V1 Effective date: Ref country code: DK Ref legal event code: EBP Ref country code: CH Ref legal event code: PL Video venöse Ulzera country code: SE Ref legal event code: EUG Ref country code: ES Payment date: Year of fee payment: 6 Lapsed in a contracting state announced via postgrant inform.
A device for coagulating body tissue contains an electrode arrangement comprising a Ulzera verwendet, wobei arterielle und venöse Blutungen.
Увидев первые же показания, врач запросила подробную информацию, касаясь кнопок одним из щупалец. Что-то в этом абсурдном имени тревожно сверлило его Video venöse Ulzera. Неужели никто никогда не сможет заменить меня на посту общей матери. http://newohioreview.com/blog/creme-zur-behandlung-von-krampfadern-sauber-beine.php сейчас ее убью.
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GMS German Medical Science — an Wundheilung, chronische venöse Unterschenkel- Ulzera From the video sequences a clear indication as to the.
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GMS Hygiene and Infection Control. immunmodulierende Effekte, akute Wunden, chronische venöse Unterschenkel- Ulzera, in two infrared thermography video.
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The inventive biomedical foam articles are suitable especially for treating chronic wounds. Video ; Documenti; Altri chronisch- venöse Ulzera der Beine.
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The inventive biomedical foam articles are suitable especially for treating chronic wounds. Video ; Documenti; Altri chronisch- venöse Ulzera der Beine.
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